Forgive the pretensions of those two words, in regards to this blog, both words refer to the bigger picture perspective. The biggest picture perspective. You will die, life will pass very quickly, and probably the only meaning in life is that of which you attribute to it.
Therefore, instead of psychologically denying those ideas, using avoidance-based coping strategies, or just letting those ideas brush over your head, it’s important to really thoroughly recognise the reality. Meditate on the reality and stain it into your mind, so that you can transcend the insignificant minutiae of everyday life and focus on what’s really important.
Place your focus on what’s important, learn the big ideas, see through the illusions, and get out of your own way.